Antimicrobial Agents & Antibiotics

CLASSIFICATION OF ANTIBIOTICS BASED ON SPECTRUM AND MECHANISM OF ACTION

Antibiotics can also be classified into different categories depending on their mode of action and/or spectrum of activity. BETA-LACTAM ANTIBIOTICS Beta-lactam antibiotics are group of naturally-synthesized antibiotics that inhibit the synthesis of cell wall in bacteria. Some later beta-lactam drugs such as methicillin, ampicillin and amoxicillin amongst others are synthesized by chemical processes. Beta-lactam drugs […]

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SPECTRUM OF ACTIVITY OF ANTIMICROBIAL AGENTS

The growth of pathogenic microorganisms is usually accompanied by the synthesis of new molecules including DNA, RNA and proteins. Microorganisms also acquire nutrient molecules from their surrounding environment or growth medium as their cells multiply and divide either in vivo or in vitro. Every drug has particular target site on pathogenic microorganisms when administered; and

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Overview of antimicrobial agents (antibiotics)

Ever since their discovery some decadesago, antimicrobial agents particularly antibiotics have saved mankind from the morbidity and mortality of innumerable infectious diseases and/or pathogenic agents even till date. Irrespective of the fact that pathogenic microorganisms have developed resistance genes or traits that allow them to dodge the antimicrobial onslaught of these agents or drugs, antimicrobial

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Chromogenic culture media for detecting antimicrobial resistance mechanisms

Chromatic Super CAZ/AVI Chromogenic medium for detecting Ceftazidime-avibactam resistant Gram-negative bacteria. Chromatic Super CAZ/AVI is a selective and differential chromogenic medium used for screening ceftazidime-avibactam resistance in Enterobacterales and Pseudomonas aeruginosa. Chromatic Super CAZ/AVI is not intended to diagnose infection or guide therapy. Results can be interpreted after incubation for 18-24 hours. Subculture to a non-selective

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CLASSES OF ANTIBIOTICS

There are several classification/types of antibiotics today, which is based on bacterial spectrum of activity (whether broad or narrow) or type of activity exhibited by the agent (whether bactericidal or bacteriostatic). Some antibiotics are also classified based on their chemical structure. And this leaves antibiotics within a particular structural class to have similar patterns of

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SOURCES OF ANTIBIOTICS

Before the advent of conventional medicine used in clinical medicine today for the treatment of infectious diseases, people in ancient times and even now have been using some herbal plants traditionally for centuries to combat microbes that cause diseases in man. Recently, scientists have studied and reported results that support the use of these herbal

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BRIEF HISTORY OF ANTIBIOTICS

Antibiotic history dates back to 1928 when Sir Alexander Fleming discovered the antibacterial effects of the yeast, Penicillium notatum, a Fungus in his laboratory. The “antibiotic era” was ushered in through the work of several pioneering scientists including Sir Alexander Fleming, Howard Florey, Ernest chain, Selman Waksman, Albert Schatz, Paul Ehrlich to mention but a

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Antibiotic Resistance / Antimicrobial Resistance (AMR), Antimicrobial Agents & Antibiotics, Antimicrobial Susceptibility Testing (AST) & Antibiogram, Pharmaceutical Microbiology, , ,

DEFINITION OF AN ANTIBIOTIC

There is no consensus to the definition of antibiotics. But it is very important that we do not displace the key points (“Killing and Inhibition”) that must be contained in any definition of an antibiotic. Abinitio, an antibiotic was originally defined as a substance produced by one microorganism, which inhibits the growth of other microorganisms.

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Introduction to Antibiotic Resistance

In recent times, antibiotic resistance of pathogens to drugs (antibiotics) directed towards the degrading properties of microbes in vivo has been on the increase both in the community and in the hospital. Antibiotics are exceptionally vital in clinical medicine for the treatment of bacterial related infections, but unfortunately bacteria are capable of developing resistance to

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Pharmaceutical Microbiology, Antibiotic Resistance / Antimicrobial Resistance (AMR), Antimicrobial Agents & Antibiotics, Antimicrobial Susceptibility Testing (AST) & Antibiogram