BETA-LACTAMASE

BETA-LACTAMASE: an important resistance mechanism in bacteria

Beta-lactamases are enzymes secreted by both Gram positive and Gram negative bacteria, and which have the ability to hydrolyze (breakdown) beta-lactam antibiotics. Beta-lactamases are responsible for bacterial resistance to broad class of-beta-lactam antibiotics, including the penicillins, cephalosporins and carbapenems. They provide antibiotic resistance in pathogenic bacteria by breaking the antibiotic structure, thereby leaving a molecule […]

BETA-LACTAMASE: an important resistance mechanism in bacteria Read More »

Antibiotic Resistance / Antimicrobial Resistance (AMR), Antimicrobial Susceptibility Testing (AST) & Antibiogram, Pharmaceutical Microbiology, ,

NITROCEFIN TEST FOR BETA-LACTAMASE PRODUCTION

The production of beta-lactamase enzymes by Gram negative bacteria including E. coli, P. aeruginosa and Klebsiella species is an important mechanism by which the organisms evade both in vivo and in vitro antimicrobial onslaught. Beta-lactamase production by resistant test isolates can be evaluated for beta-lactamase production using the Nitrocefin test sticks (Oxoid, UK). The nitrocefin

NITROCEFIN TEST FOR BETA-LACTAMASE PRODUCTION Read More »

Antibiotic Resistance / Antimicrobial Resistance (AMR), Pharmaceutical Microbiology, , ,