MICROBIAL DISEASES TRANSMISSIBLE THROUGH THE SOIL

by DrChika

Microorganisms are ubiquitous and are thus found everywhere including the soil. The soil no doubt is inundated with a wide variety of microorganisms including those that are pathogenic to humans, plants and animals and even microbes that are of immense industrial and economic importance to mankind and his environment. For example, the first commercial antibiotic penicillin was originally and naturally sourced from Penicillium species especially P. notatum and P. chrysogenum, which are prominent microbes found in the soil.

The soil is a dwelling place to a wide array of microorganisms including bacteria, protozoa, helminths, fungi and some viruses which cause a handful of disease in humans (Table 1).

Table 1. Microbial diseases transmissible through the soil

ORGANISMDISEASECLINICAL SYMPTOMSPREVENTION/CONTROL/TREATMENT
  BACTERIAL DISEASES  
Clostridium perfringens Gas gangreneProgressive necrotic skin/wound lesion, fever, toxemia, foul-smelling discharge, and shock  Early and adequate cleansing of contaminated wounds and surgical debridement. Administration of penicillin and polyvalent antitoxin are used for treatment.  
Yersinia enterocoliticaYersiniosisAbdominal pain, diarrhea and feverConventional sanitary precautions and avoiding contact with animal droppings or feaces. Chloramphenicol, tetracycline and aminoglycoside are used for treatment.  
Clostridium botulinumBotulismRespiratory paralysis and gastrointestinal upset.Vegetables, fruits and other raw materials for food production should be kept away from soil contamination; and they should be properly washed and cleaned before use. Maintenance of adequate ventilation using mechanical respirator is vital to ensure proper airflow. Antitoxins are administered in cases of botulism.    
Bacillus anthracisAnthraxSymptoms vary with the location of the disease. Fever, malaise, skin oedema, headache and GIT symptomsActive immunization, use of protective clothing’s when handling infected materials, infected animal carcasses should be burned or buried deeply. Ciprofloxacin, penicillin G and erythromycin are used for treatment.        
Campylobacter jejuniCampylobacteriosisProfuse diarrhea, abdominal pain, fever and malaise  Food should be properly cooked and protected from feacal contamination by animal droppings.  
Actinomyces israeliiActinomycetomaSwollen, erythematous process in the jaw area, cough, mild fever and purulent sputum  Administration of erythromycin and clindamycin as well as prolonged administration of penicillin is used for treatment.  
Clostridium tetaniTetanusGeneralized muscular spasm especially lockjaw trismusPiercing of the skin especially with sharp objects should be followed with active immunization with tetanus toxoids. And antibiotics (e.g. penicillin) should be administered in cases of wound infection.  
Listeria monocytogenesListeriosisIntrauterine sepsis and bacteraemiaAmpicillin, sulphamethoxazole-trimethoprim and erythromycin are used for treatment.  
Leptospira interrogans LeptospirosisJaundice, haemorrhage, and lesions of the eye, skin andExposure to feacally contaminated soil should be prevented; and workers who come in regular contact with soil such as farmers, sewer workers and miners should always do so in their protective clothing. Doxycycline is used for treatment.  
Coxiella burnetiiQ feverNausea, headache, vomiting, myalgia, diarrhea, myalgia, abdominal and/or chest pain and non-productive coughChloramphenicol, tetracycline, and sulphonamides.          
Borrelia burgdorferiLyme diseaseFever, chills, headache,  and malaise  Prevention of the lyme disease is based on avoiding exposure to ticks and lice especially during delousing of furniture’s and other dust-ridden materials.  
Francisella tularensisTularemiaJoint stiffness, muscle pain, malaise, headache and chills  Avoidance of soil contaminated with animal droppings is a key preventive measure. Tetracycline, streptomycin or gentamicin is used for treatment.    
                FUNGAL DISEASES  
ORGANISMDISEASECLINICAL SYMPTOMPREVENTION/CONTROL/TREATMENT    
Aspergillus speciesAspergillosisSymptoms vary with the type of aspergillosis in a patient. Allergic skin reactions, dyspnea, fatigue, weight loss, and feverExposure to conidia of the microbe should be avoided. And itraconazole, amphotericin B and surgery (in some cases) are used for treatment.              
Blastomyces dermatitidisBlastomycosisChronic pneumonia, myalgias, malaise, night sweats and feverAvoid inhalation of dust particles (because they may contain the conidia of the organism) and contact with animal droppings especially those of dogs. Amphotericin B and itraconazole are used for treatment.  
Coccidioides immitisCoccidioidomycosisChronic but progressive pulmonary disease. Arthralgia, malaise, fever, headache and coughReducing dust, paving of airfields and road, and planting of grasses and using oil sprays on exposed soils are some preventive/control measures. Amphotericin B, itraconazole and fluconazole are effective for treatment.     
Histoplasma capsulatumHistoplasmosisCoughing up blood, fever, chills, neck stiffness, mouth sores, skin lesions and chest painsAvoid exposure to dust and wind. Dust usually contain conidia of the organism; and people who work in occupations where dusts are raised should always were protective face masks to avoid the inhalation of dust particles which is likely to contain conidia of H. capsulatum. Itraconazole and amphotericin B are used for treatment.  
Sporothrix schenckiiSporotrichosisDevelopment of red lump at the site of infection, facial lesions, necrotic ulcerative lesionsPrevention includes measures to reduce accidental introduction of the conidia into the body. Woods should be treated with fungicides to avoid aerosolization of spores. Itraconazole and amphotericin B is used for treatment.  
Pseudallescheria boydiiMycetomaSuppuration and abscess formation in subcutaneous tissues of the lower extremities of the hands and feet Wounds should be properly cleaned and avoid contact with soil during the process of healing. People who work in occupations that involve direct contact with the soil should always wear protective clothing and foot wears to avoid contracting the agent form the soil. Amphotericin B, itraconazole and ketoconazole are used for treatment.  
Rhizopus species and Mucor speciesMucormycosisThrombosis, infarction and necrosis due to the germination of the sporangiophores of the causative agent(s) in the nasal carriage of the individualMucormycosis is an opportunistic fungal disease or mycoses common in immunocompromised individuals; and the best preventive measure is usually the maintenance of a good immune system. And infection is also common in areas were tornadoes are experienced due to the aerosolization of spores from the soil into the air. Amphotericin B is used for treatment of the disease.    
VIRAL DISEASES     It is noteworthy that human viruses have no functional biological role within the soil environment; and this is because viruses unlike other microbes only exist and multiply inside a living host cell. Viruses hardly multiply outside a living host cell. However, some viruses such as the polioviruses and Enteroviruses can survive for sometime within the soil environment. For example, Enteroviruses are usually shed in large amount for longer periods of time in the stool of human reservoirs; and the feacal contamination of food, water and other materials by these viruses especially through the soil are common route via which the pathogen is transmitted in human population”.
ORGANISMDISEASECLINICAL SYMPTOMPREVENTION/CONTROL/TREATMENT    
Enteroviruses (Human enteric viruses)  Enterovirus infection. They cause GIT infections in humans; and they can also infect the central nervous system (CNS) tooInfantile diarrhea, muscle weakness, conjunctivitis and spasmEnteroviruses can survive for extended periods in the soil environment; and thus prevention/control is largely depended on avoiding unnecessary contact with soil especially those that are feacally contaminated. Contact with human excreta or sewage which is usually in the soil is a common means of contracting the disease agent. Treatment is usually based on the use of antiviral drugs since there is no specific antiviral agent for the treatment of Enterovirus infection in humans.  
HantavirusHantavirus infection such as hantavirus pulmonary syndrome and haemorrhagic fever with renal syndromeFlu-like at onset of the disease. Difficulty in breathing, coughing, stomach pain, dizziness, headache and diarrhea.Human contact with the excreta of infected rodents in the soil is a common means by which the hantavirus infection is spread in human population. And the direct inhalation of aerosolized viral particles especially during tillage of the soil is another common medium of transmission of hantavirus. Thus, protective face mask should be worn by people who work in occupations where dust particles are easily aerosolized such as in road construction and farming. Avoidance of contact with the droppings of rodents is vital to the prevention/control of hantavirus infection. Ribavirin is usually used for treatment.
PROTOZOAL DISEASES
ORGANISMDISEASECLINICAL SYMPTOMPREVENTION/CONTROL/TREATMENT    
Entamoeba histolytica AmoebiasisSymptoms of amoebiasis vary depending on the site of the infection and the intensity of the lesion caused. Loss of appetite, weight loss, abdominal cramp, diarrhea, nausea and vomitingSince asymptomatic carries of Entamoeba histolytica are usually the main source of contamination and such persons release the cysts of the parasite in their excreta which may contaminate the soil via indiscriminate defecation and sewage leakage, it is vital to improve environmental sanitation to avoid contamination. Sewage and human feacal matter should not be used as organic manure in crop cultivation. Metronidazole or flagyl is the commonest drug used to treat amoebiasis.  
Balantidium coliBalantidiasisSevere fluid loss, watery and bloody stooling, weight loss, abdominal pain, headache, vomiting, headache, fever and loss of appetiteIngestion of viable cysts of B. coli passed via the stool of pigs and humans is usually the commonest route of contamination. Cysts of B. coli can be ingested via food especially in slaughter houses where feacal contamination of food is possible. Improvement on environmental sanitation reduces the contamination of the infection. Metronidazole and oxytetracycline are usually used for treatment.  
Cryptosporidium parvumCryptosporidiosisAbdominal cramp, nausea and low-grade feverIngestion of feacally contaminated food or water (especially human and animal excreta) is a common source of contamination with C. parvum. Farmers who come in contact with animal excreta are also at risk of contamination. Thus, avoidance of animal excreta especially in feacally-contaminated soil is vital to the prevention and control of the disease. The disease is usually self-healing especially in individuals with strong immunity. However, antiprotozoal agents can be administered to immunocompromised individuals with the infection.    
Cyclospora cayetanensisCyclosporiasis  Weight loss, malaise, abdominal cramp and fatigueThe disease is caused by the ingestion of cysts of the parasites via food or water. Thus, food and raw materials for food production should be preserved and protected from feacally-contaminated soil. Bed rest is recommended in mild cases of the disease. Sulphamethoxazole-trimethoprim and ciprofloxacin are usually administered for treatment especially in severe cases and in immunocompromised patients.  
Girdia lambliaGirdiasisVomiting, diarrhea, abdominal cramp, malaise and flatulenceIngestion of feacally-contaminated water or food is a common route via which the disease is spread. Avoidance of feacal-contamination of these products is important to the prevention/control of the disease. Metronidazole or flagyl are used for treatment, but treatment is only recommended for asymptomatic individuals i.e. patients who show clinical signs of the disease.     
Isospora belliIsosporiasisMyalgia, headache, offensive smelling diarrhea, abdominal cramp, low-grade fever and loss of appetite  The disease like cyclosporiasis is caused by the ingestion of cysts of the parasites via food or water. Thus, food and raw materials for food production should be preserved and protected from feacally-contaminated soil. Bed rest is recommended in mild cases of the disease. Sulphamethoxazole-trimethoprim and ciprofloxacin are usually administered for treatment especially in severe cases and in immunocompromised patients.  
Toxoplasma gondiiToxoplasmosisLymphadenopathy (swollen lymph nodes), dyspnea and non-productive coughHuman contact with the droppings or feaces of domestic animals including cats should be avoided as a measure of prevention/control. Sulphamethoxazole-trimethoprim, clindamycin and pyrimethamine are used for treatment. 

It is a multilayered surface of the earth crust made up of mineral and organic constituents that harbours a huge biodiversity of life that supports several biological processes of microorganisms, humans, plants and animals. The microorganisms found in the soil have several biological functions in the soil such as providing support to the ecosystem as well as proving growth support to plants and improvement of the fertility of the soil. The soil is also home to small animals such as rodents, snails and nematodes, and they give mechanical and protective support to plat roots. Microorganisms that are innately found in the soil help in the cycling of nutrients in the ecosystem.

The soil is home to microbes that are of immense economic, health and industrial importance; and several antibiotics and/or antimicrobial agents have their source from microorganisms (especially bacteria and fungi) that dwells in the soil.  Though they contain numerous microbes that are beneficial to mankind, animals, plants and the environment, the soil also contain microorganisms which are capable of causing diseases in humans and even in other animals and plants as well. Microbes that are found in the soil and which cause disease in humans and animals are generally known as soil-borne pathogens.

Most of these soil-borne pathogens are opportunistic pathogens, and they take advantage of the immune system status of susceptible individuals especially people who are immunocompromised (e.g. AIDS patients) to cause infection or disease. Soil-borne pathogens are able of surviving for long periods of time within the soil environment until they find a suitable human host to infect. Human infections with soil-borne pathogens is usually common amongst people who come into direct contact with contaminated soil especially soil contaminated with feacal matter of animal and human origin.     

References

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