selective toxicity

PAUL EHRLICH (1854-1915)

Systematic work on antimicrobial drugs was first initiated by the Germanphysician Paul Ehrlich. Ehrlich worked in the fields of haematology, immunology, and chemotherapy. He coined the term “chemotherapy” and also developed the concept of “selective toxicity in the early 1900s”, which is “the ability of an agent to inhibit or kill pathogenic microorganisms without any […]

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General Microbiology, ,

SPECTRUM OF ACTIVITY OF ANTIMICROBIAL AGENTS

The growth of pathogenic microorganisms is usually accompanied by the synthesis of new molecules including DNA, RNA and proteins. Microorganisms also acquire nutrient molecules from their surrounding environment or growth medium as their cells multiply and divide either in vivo or in vitro. Every drug has particular target site on pathogenic microorganisms when administered; and

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Antimicrobial Agents & Antibiotics, Pharmaceutical Microbiology, , , , , , , , , ,