carbapenemases

METALLO-β-LACTAMASE (MBL) – detection methods

Metallo-beta-lactamases (MBLs) are beta-lactamase enzymes produced by pathogenic bacteria, and which hydrolyzes the carbapenems (e.g. imipenem, meropenem, and ertapenem) and render the antibiotics ineffective for treatment. They are encoded by genes that have been procured by pathogenic bacteria either by mutation or by horizontal gene transfer from other resistant microbes. MBLs efficiently hydrolyze all beta-lactam […]

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Antibiotic Resistance / Antimicrobial Resistance (AMR), Antimicrobial Susceptibility Testing (AST) & Antibiogram, Microbe Lab, Pharmaceutical Microbiology, , ,

BETA-LACTAMASE: an important resistance mechanism in bacteria

Beta-lactamases are enzymes secreted by both Gram positive and Gram negative bacteria, and which have the ability to hydrolyze (breakdown) beta-lactam antibiotics. Beta-lactamases are responsible for bacterial resistance to broad class of-beta-lactam antibiotics, including the penicillins, cephalosporins and carbapenems. They provide antibiotic resistance in pathogenic bacteria by breaking the antibiotic structure, thereby leaving a molecule

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Antibiotic Resistance / Antimicrobial Resistance (AMR), Antimicrobial Susceptibility Testing (AST) & Antibiogram, Pharmaceutical Microbiology, ,